Geometric and Histopathologic Assessment of Yarrow Extracts (Achillea millefolium) and on Healing of Experimental Skin Wounds and its Comparison with Zinc Oxide on Rats

Skin wound healing especially when it occurs on the face or somewhere important for cosmetic reasons, is very significant physiological procedure. It is quite obvious that promoting this healing is important too. In this study we tried to compare the effects of Achillea millefolium and Zinc oxide on secondary intentioned open-wound healing in rats. Zinc oxide is being used worldwide as an absorbent and protective compound. Its pharmacological properties are wide and its non-toxic material allows it to be used as a routine skin care substance. In current study, 70 female wistar rats where included in 5 groups. Full thickness Incisional wound with 23 mm diameter was made with surgical scissors and scalpel. The whole operation was taking place under general Anesthesia and analgesia circumstances. After making surgical wounds, rats are treated as mentioned in the text. Rats are observed for 28 days for wound closure process and inflammatory conditions taking place in wound. Biopsy intervals are 0 (the day of surgery), 3, 7, 14, 21 and 28th day after surgery. In these certain days rats were euthanized and biopsies of wound sites were obtained. Wounds areas are also measured by Scion Image TM software daily. At last, all data were analyzed using SPSS statistics ver.17. As a result, Achillea millefolium at the dose of 10% has significant healing properties compared to Zinc oxide. These data were validating under confidence surface of 95% (p<0.01).